Demalonyl derivatives of azalomycin F4 and scopafungin.

Demalonyl derivatives of azalomycin F4 and scopafungin.

Isolation of three main components. F3, F4 and F5, from azalomycin F-complex.

Isolation of azalomycins F3, F4 and Fg from azalomycin F-complex crystals was successfully conducted. F3 was less soluble in methanol than other components and was isolated by fractional crystallization of F-complex from 80~ 100% methanol in water. F4 and F5 were separated by P-cellulose column chromatography, from which F5 and F4 were eluted with 60 % aqueous methanol and 0.01M ammonium acetat...

Scopafungin, a crystalline endomycin component.

Scopafungin is the major component of the non-polyenic endomycin complex which was extracted from Streptomyces hygroscopicus var. enhygrus var. nova and purified by partition column chromatography or silica gel column chromatography followed by crystallization. It is a white crystalline compound which contains carbon (60.95%), hydrogen (9.00%), nitrogen (4.01 %) and oxygen (26.46 %) and melts a...

determination of olanzapine and thiourea using electrodes modified by dna and film of copper-cobalt hexacyanoferrate & investigation of electro-oxidation of some catechol derivatives in the presence of 4-phenylsemicarbazid

چکیده هدف از این کار بررسی الکترواکسیداسیون کتکول و مشتقات آن در حضور 4-فنیل سمی کاربامازید بوده است اکسیداسیون کتکولها ترکیبات نا پایدار کینونها را تولید می کنند که این ترکیبات می تواند در واکنش مایکل بعنوان پذیرنده نوکلئوفیل عمل نمایند. در ادامه اکسایش کتکولهای (a-c1) را درحضور 4-فنیل سمی کاربامازید در محلول آب/استونیتریل (90/10)بوسیله ولتامتری چرخه ای و کولن متری در پتانسیل ثابت مورد بررسی ...

Effect of azalomycin F on bacteria.

It has previously been reported that azalomycin F could induce permeability changes in Candida albicans causing loss of cell constituents and inhibition of substrate uptake which resulted in the death of the organism1). The present report is concerned with the effect of the antibiotic on bacteria. Methods and Results Azalomycin F inhibited the growth of Bacillus subtilis PCI 219 at concentratio...